Is possible to explain to me the details of the method of preparation of Poloxamer gel?

Reyhaneh Sam @Reyhaneh-Sam

29 January 2023 1 7K Report

Hi dear Amir Fakhari

I am Reyhaneh Sam, Ph.D. student of Pharmaceutics at Kerman university of medical sciences.

I need to know how can I use Poloxamer 407 powder from Sigma Aldrich to see its thermoresponsive properties.

Sayoni Maitra

Hi Reyhaneh Sam ,

Poloxamer gels are conventionally prepared by the “hot” or the “cold” process. But these techniques have some disadvantages such as high energy consumption, requires expensive equipment and often have scale up issues. Therefore, the objective of this (attached) work was to develop poloxamer gels by hot-melt extrusion technology.

[ Authors: Nicole S. Mendonsa, S. Narasimha Murthy, Seyed Meysam Hashemnejad, Santanu Kundu, Feng Zhang, Michael A. Repka]

Hope you find it useful.

regards

Sayoni

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