I'm preparing PF-8380 (HY-13344 from MCE) for intraperitoneal administration in mice and considering PEG300 as the sole solvent, as I can dissolve PF-8380 smoothly with pure PEG300, but as soon as I add saline, it becomes turbid immediately. Would that be okay?
Lucian Miles
Hello, Marine Ma
It is not recommended to inject pure PEG300 because the viscosity is too high. After adding normal saline, it can be assisted by ultrasonic cleaning at 37℃ ultrasonic heating to obtain a uniform suspension that can be injected intraperitoneally.
We tested PEG300+normal saline and it was also in a suspension state.
The answer to this question comes from MedChemExpress (MCE) Technical Support.
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