ibuprofen has low dissolution in acidic pH, if ibuprofen formulated into effervescent floating tablet, is it good for its bioavailability ?
Hi!There are so many trademarks of ibuprofen drug in soft gelatine capsules, with dissolution exactly in the gastric, so, in my opinion, it won't be any significant problem with its bioavailability. I have found one drug which has ibuprofen in such dosage form: Anadin Liquifast Ibuprofen 200mg Effervescent Tablets10. Also, this links may help you in better understanding and solve your problem:
http://globalresearchonline.net/journalcontents/v43-2/36.pdf
https://www.jpharmsci.org/article/S0022-3549(16)41468-1/pdf
Best regards!
To the best of my knowledge, ibuprofen does have good oral bioavailability (80-100%)
https://en.wikipedia.org/wiki/Ibuprofen
If the aim of this research is to develop and investigate a particular dosage to improve oral bioavailability, then you may wish to consider an alternative model drug.
I would personally look at class IV drugs. Or class II that are known to have a poor oral bioavailability due to poor solubility. i.e. their rate of oral absorption depends on their dissolution rate.
You may find the link below useful to help you chose an appropriate drug candidate:
https://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm128219.htm
I am sure that the current options available for Ibuprofen in the tablet dosage form are quite established. It would be a good idea to look at Class II and IV drugs as Professor Raid mentioned.
Ibuprofen also has a bad/burning taste which would need to be masked for such a product. As answered above, there will be no performance improvement since a simple tablet is quickly and effectively absorbed. With all of the competition, it would take a large and expensive marketing campaign to have good sales which would likely not be economically viable with the low price margin.
What is the means of adding effervescent in floating tablet, when tablet is effervescent, it will take hardly fraction of seconds to be disintegrated.
To my knowledge ibuprofen causes peptic ulter.so why not go for enteric coated?
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