We observed increased levels of some anti Inflammatory cytokines in the serum samples of MDD patients. We hypothesised that neuroinflammation might involve in depression and in that case antiinflammatory cytokines were supposed to decrease during depression to support this hypothesis. Now how we can explain this elevated antiinflammatory cytokines in depression?
Maybe, it is one of those games of the body. I mean, the working mechanism of the body generally does not fit in the mould. So if we ratiocinate in an orthodox way, we can miss some complicated mechanisms involved in the situation we consider. Therefore, with a shot in the dark, an increase of anti-inflammatory cytokines may stem from a compensation mechanism against the rise of inflammatory cytokines.
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