Use of parametric tests for not normally distributed data - central limit theorem?

Can we use parametric tests for data that are not normally distributed based on the central limit theorem, especially if we have a large sample size?

10 November 2019 6,253 39 View

Survey of the public regarding bleeding control?

Could anyone provide me with a propsed survey on public awarness regarding bleeding control in mass-casualty incidents?

03 April 2018 2,931 1 View

Any short & free online course to learn R programming?

I need a short online course to learn R programming within a few weeks. Thanks!

08 September 2017 9,872 7 View

How do the ranking agencies/websites rank medical schools in terms of research contribution?

07 August 2017 4,921 2 View

Does anyone have a well-summarized source for medical teaching methodology?

Does anyone have a well-summarized source for medical teaching methodology?

07 August 2017 4,002 11 View

The pulse may vary in volume between the two arms e.g in case of aortic dissection, but is there any cause for pulse variation in its rate?

Cardiology, Physiology, Internal Medicine

09 October 2016 5,895 9 View

Is there any evidence for anticipating eye color inheritance in the offspring using this chart?

Genetics, Ophthalmology, NIH, PubMed, Cochrane, EBM, Evidence

02 March 2016 9,947 1 View

How to write a case report in a proper way? what are the most commonly used journals by medical students to publish their papers?

Case report, EBM, Medical students, PubMed, BMJ ..

02 March 2016 7,829 0 View

Which is more accurate definition of projectile vomiting?

Which is more accurate definition of projectile vomiting? (not preceded by nausea or forcefully ejected & to a large distant ) History, Examination, Definitions, Medicine, Gastroenterology

01 February 2016 6,086 2 View

Could anyone suggest a free-online & reliable website to publish a survey questionnaire, please?

Research, Questionnaire, Survey

01 February 2016 1,040 1 View

No title

02 March 2021 3,060 3 View

Issues with Permeabilization during Flow Cytometry?

Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...

01 March 2021 3,867 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is it possible for two human neuronal cell lines to have different gene sequence for the same protein?

I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....

01 March 2021 3,607 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Do you need the CMV enhancer before the CMV promotor for a proper function of CMV on the gene that follows?

I'm a student and I have to produce a cell line with a knockin for the NRF2 gene with GFP. I have to put a promotor in front of the GFP because the gene will be too far away from the promotor of...

28 February 2021 7,127 2 View

What could be some reasons why unstimulated monocytes are getting activated?

Im doing PBMC isolation -> CD14+ enrichment using magnetic beads -> stimulation setup. My negative control is just cells in cRPMI but they seem to get activated over and over again.

28 February 2021 7,883 3 View

No title

28 February 2021 9,936 2 View

What is the exact mechanism of the antimicrobial effect of local anesthetics?

The antimicrobial effect of local anesthetics has been known for more than 50 years, but it still seems to have an unclear mechanism of action. which bacteria? which concentration? etc etc. ....

27 February 2021 4,450 2 View

Has anyone had luck using cell lines other than HEK 293 (such as COS1) to package lentivirus?

I am looking to package lentivirus in endothelial cells but I am opposed to using 293 cells due to personal ethics regarding the source. I have done some reading and saw that COS1, COS7, & CHO...

25 February 2021 3,030 1 View