By means of co-culture they induce mesenchymal stem cell to form keratocytes. I'd like to know how we can induce MSC to form either corneal stromal cells or corneal keratocytes using medium.
Dear Revathi,
MSCs are part of corneal stroma (link below). I mean, MSC purpose there is to support reconstitution/remodeling of stroma. Referring to cell cultures, you need respective stimuli to make desirable happen, e.g., FGF.
There are several research groups working in this MSC perspective. You can contact to them for support:
Role of Human Corneal Stroma-Derived Mesenchymal-Like Stem Cells in Immunity, Wound Healing and Angiogenesis.
Reka Albert1A,1B, Zoltan J. Vereb1C, Morten C. Moe2, Laszlo Fesus1A, Eva Rajnavolgyi1C, Andrea Facsko3, Andras Berta1B, Goran Petrovski1B,1A. ADepartment of Biochemistry and Molecular Biology, BDepartment of Ophthalmology, CDepartment of Immunology, 1University of Debrecen, Debrecen, Hungary; 2Dept of Ophthalmology, Oslo University Hospital, Oslo, Norway; 3Department of Ophthalmology, University of Szeged, Szeged, Hungary.
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=2866&sKey=17f907af-68c9-4dd4-b9da-74301a9f411a&cKey=008153d5-df70-4ac0-994b-1c6ff9d16f69&mKey=f0fce029-9bf8-4e7c-b48e-9ff7711d4a0e
Regards
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