I had performed homo lumo calulation of abametapir molecule (C12H12N2)in different polar and non polar solvents like water , DMSO, DIETEHYL ETHER , CCL4. THE frontier energy gap in polar solvents (water, dmso) are found to be larger nearly 5.03 eV than that in non polar solvents nearly 4.77eV.If so molecule possess kinetic stability in water, dmso phase and chemically active in CCl4 and diethyl ether. But theory I found in many article show that compound are chemically reactive in polarize solvent and stable in non polar solvent. Is it ok to have stabilty in polar solvent and chemically active in non polar solvent. I am totally confused about my task , i have optimized molecule with frequency calculation and perform molecular orbital job but can not do analyze the result. If anybody know help me please