In recent years there has been ample evidence demonstrating the critical role played by macrophages in chronic inflammatory diseases. While depletion of a particular subtype by antibody dependent method or by other marker dependent depletion, it may not be the best way to deal with this. If we could find a way to polarize or program by other means say harmless nutritional supplement or by a small molecule with a short life that could be tied to nanotechnology it may be of immense value.

I am wondering is there technology or technologies in progress that are addressing these issues at present? In case you are working on these lines, can you throw some insightful comments on this topic? I would greatly appreciate it.

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