I think if we block the porins or TonB-dependent transporters? of bacteria and prevent them from transporting important compounds, we can destroy them. I appreciate if you share your experience.
Polyamines spermine and cadaverine are known inhibitors of bacterial porins. But an idea of using these inhibitors as antibacterials is contradicted by reports showing increased resistance to toxic metals and antibiotics in bacteria treated with porin inhibitors; these reports show that porins play important role in bacterial uptake of toxic compounds. What if stimulating (rather than inhibiting) bacterial porins is more likely to produce a synergistic effect with antibiotics?
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Dear Martin,
Thank you for your comment. Yes, we can design compounds to stimulate porins to transport antibiotics better such as what ampicillin does.
Porins provide a path through the OM to small hydrophilic antibiotics, such as β-lactams, as well as tetracycline, chloramphenicol and fluoroquinolones.
Any decrease in the ability or rate of entry of these compounds can lead to resistance ,so the answe is YES, we can possibly design drugs against bacterial porins.
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