The reason why sporozoites of the five species of malarial parasite can infect hepatocytes is because the gene expressions patterns in hepatocytes are suitable for sporozoite infections. Therefore, alteration of gene expression patterns in hepatocytes will reduce the susceptibility to sporozoite infections. Perturbation of 3D genome architecture could change gene expression patterns. Many research results have shown that X-ray irradiation can change 3D genome architecture, leading to alteration of gene expression patterns. We assume that a low-dose X-ray irradiation of the whole liver might protect people from malaria infections for a long time (hopefully, more than one year). Therefore, X-ray irradiation could be a non-antigen-based “vaccine” to prevent all malaria infections. Certainly, this theory needs experimental and clinical trials to prove.
Poster Malaria Eradication "Vaccine": X-Ray Irradiation of the Whol...
Series of studies have be conducted on malaria vaccine production, however recent research have proven that x-ray irradiation of the liver can be used to treat malaria infection. Example the studies by Eric James et al 2022, clinical trials using live humans revealed success of liver irradiation in treatment of malaria infection.
James ER, Matheny S, Overby J, Sim BKL, Eappen AG, Li T, Li ML, Richie TL, Chakravarty S, Gunasekera A, Murshedkar T, Billingsley PF, Hoffman SL. A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria. Front Immunol. 2022 Feb 15;13:851028.
This paper has nothing to do with what I asked here. Till today, no papers have reported that X-ray irradiation of the whole liver could prevent malaria infections.