I am attempting to conduct a SR with a meta-analysis on a cardiology condition that is not often reported. There are a few retrospective studies, but many more case reports / case series. Based off my cursory search online, the answer to my question I believe is yes, but I wanted to make sure before I embark on this project.
I suspect there will be quite a lot of heterogeneity in my patient population.
Thank you in advance!
In my opinion , meta-analysis.usually based on systemic review , observation study or experiment study . Observational study includes case series, case study . Definitely you can conduct meta -analysis based on case series or case study but this meta-analysis will not draw evidence based conclusion as RCT
It is not suitable. It is appropriate to use data from randomized clinical trials.
In my opinion, meta-analysis must included studies with primary data, it cannot extract from case report/case series even if the case rarely reported. In order to minimize bias, based on Cochrane Handbook for Systematic Review, you should conduct it at least 2 investigators
Yes you can conduct meta-analysis based on case series but conclude weweak evidence
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