I have determined cytotoxic affect of my plant again 3T3 cells by MTT assay. And it showed % 8 inhibition.

Now I want to use this extract for in vivo study on animal model. Can I decide a plant dose 200mg/ml for animal on the basis of cytotoxic results. As the plant extract is harmless to normal cells. Or I have to find out phytotoxicity in animal model too.

Plz explain it.

Regards

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