Cancer is probably the first leading cause of breast soft tissue defects that result in a need for reconstruction. Autologous platelet-rich plasma (PRP) has been already used during post-mastectomy breast reconstruction in order to enhance the survival of grafted fat. Several studies, however, have shown that the release of platelet-derived growth factors stimulates angiogenesis, induces tumor lymphangiogenesis, enhances nodal metastasis rate, regulates several cell biology processes (including proliferation, cell differentiation, migration, apoptosis and tumorigenesis), affecting overall survival.

Do you think it would be useful to establish contraindications regarding PRP application during breast reconstruction?

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