I am working on a project to determine the different inflammatory who contributes to develop acute inflammation and i found that most of the previous article concludes that IL-10 act as a anti-inflammatory can someone please tell me the signaling pathway of the acute inflammation and any evidence regarding IL-10 to cause acute inflammation.
Dear Amit Kumar Shrivastava
Although typically classified as anti-inflammatory and immunosuppressive cytokine, the effects of IL-10 are highly context-dependent and there are several scenarios where IL-10 enhances immune cell activation and proliferation causing the release of pro-inflammatory cytokines.
You will obtain more information from the research paper given below.
https://www.frontiersin.org/articles/10.3389/fimmu.2021.677008/full
Best Wishes.
Dear Amit Kumar!
You also look at the article:
Article Role of Interleukin 10 Transcriptional Regulation in Inflamm...
In vivo, major sources of IL-10 include T helper cells, monocytes, macrophages and dendritic cells, however myriad immune effector cell types are capable of producing IL-10 in certain contexts including B cells, cytotoxic T cells, NK cells, mast cells, and granulocytes like neutrophils and eosinophils.
In addition, IL-10 can positively enhance activation and proliferation of certain immune cell types, including mast cells, CD8+ T cells, NK cells, and B cells..
TABLE 1
IL-10-Associated Animal Models
V. CELLULAR SOURCE OF INTERLEUKIN 10
Amit Kumar Shrivastava
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