I was planning to simulate hypoxia chemically in cancer cells using dimethyloxalylglycine (DMOG), desferrioxamine (DFO), ciclopirox olamine (CPX) or cobalt chloride (CoCl2), due to lack of a hypoxia chamber. However, I was also wondering if the results obtained from this form of hypoxia induction comparable to hypoxic simulation in a chamber, but I only found one article for this proof related to mesenchymal stem cells: Article Hypoxia-mimetic agents inhibit proliferation and alter the m...

I have yet to find an article noting a difference between the two in cancer cells. Has anyone tried both cases and noticed a significant difference, or are they comparable? Similarly, does the agent type also affects results? I can't find any article comparing the effect of each agent in cancer cells as well. Thanks!

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