Many studies showed high dose of curcumin induces ROS formation and caspase medicated apoptosis in both fibroblasts and keratinocytes which should in theory make curcumin unfit for the treatment of cutaneous wound healing. The curcumin I have always known was cytoprotective, antioxidant, anti-inflammatory and has potent wound healing ability but these study results prove otherwise.I know Curcumin interacts with multiple pathways and has multiple pharmacological properties, so some how It might pleiotropically promote wound healing besides its cytotoxic effect on these cells.but I am not sure how inhibitory effect of curcumin on fibroblast and keratinocytes proliferation could help with cutaneous wound healing.
Article Cytoprotective responses in HaCaT keratinocytes exposed to H...
Dear Prabahkaran Selvam,
This article has some answers to your question: Molecules 2014, 19(8), 11679-11721; doi:10.3390/molecules190811679. Best regards
Dear Daniel Lerda,
Thank you for your help. But I couldn't find the article you refer me to. Could you please give me the link to the paper or just the title would do. Thank you.
Hello Mark Thomson,
Thank you so much for sharing some valuable information. The article you shared taught me some necessary knowledge about drug screening and identifying true & promising lead compounds.
Yes it is very much likely that the non-specificity of curcumin could result in some contradictory results and have poor reproducibility as you very clearly said. Besides that curcumin indeed has some great pharmacological potency. It is surprising to see curcumin that proved to be cytoprotective and induced keratinocytes and fibroblasts proliferation in animal models, induce toxicity when tested on these cell lines individually. To my knowledge this contradictory results could be due to one of two reasons or both; firstly the cytoprotective effect of curcumin in animals might have been brought about by its interaction with other cells possibly via inducing anti-inflammatory cytokines. So in the absence of those immune cells curcumin could have induced toxicity on fibroblasts or keratinocytes. Second possibility is, curcumin is very well known to induce oxidative stress in cancer cells and induce apoptosis. Now most of the studies that tested curcumin’s toxicity used immortalized fibroblast or keratinocyte cell lines which are basically cancer cells. So it is possible that because of the nature of the cell line curcumin might have caused this toxicity. I’m not too sure if anyone has tested curcumin’s toxicity on primary keratinocytes (pNHEK) or primary dermal fibroblasts or in coculture with other supporting cells through which curcumins act.
Dear Prabhakaran Selvam
The article is: "Review of Natural Compounds for Potential Skin Cancer Treatment". Best regards
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