Prabhakaran Selvam

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Questions related from Prabhakaran Selvam

Is curcumin a good candidate for wound healing besides its cytotoxic effect on Keratinocytes and fibroblasts?

Many studies showed high dose of curcumin induces ROS formation and caspase medicated apoptosis in both fibroblasts and keratinocytes which should in theory make curcumin unfit for the treatment...

30 December 2015 7,435 4 View

Is curcumin glycosylated while it is synthesised in the plant?

Most phenolic compounds in the nature are present in glycoside forms.But I don't see any paper mention that curcumin is in glycoside form in nature. All I hear is it is not water soluble so they...

05 December 2015 1,652 5 View

Should I use TLR4 agonists or antagonists to induce maximum IL10 expression in vivo?

it is a bit confusing to see both TLR4 agonsits and antagonists induce IL10 expression. Studies clearly say that TLR4 activation(by LPS) results in upregulation of IL10(IL10 would in turn result...

28 November 2015 7,490 3 View

Could the addition of a specific glycan structure to a biologically active compound change its pharmacodynamics other than just kinetics?

some research suggests that the glycan stay attached to its aglycon part while it binds to the receptor(s), in fact the glycan residues itself bind to receptor helping in longer receptor...

27 November 2015 1,751 6 View