Assertions, Hypothesis and theories emanating in literature online shows that the novel corona virus is more associated to the blood system than it is to the respiratory system. The theories have it that the virus has affinity for binding with haemoglobin as primary target that results in a compromised oxygen carrying capacity of the blood causing the secondary symptoms seen in the lungs. elevated D-dimer levels have also been reported and this scenario has created space for the recommendation of fresh packed red cell transfusion after plasmapheresis to covid-19 positive patients to ameliorate cytokine invasion. So can will conclude that Covid-19 is more associated with the blood system than the respiratory system since the primary distortion in the blood are traced to be responsible for the secondary symptoms seen in the lungs?
Evidences has shown assiciation witjh ACE2 receptors and isolated from bronchoalveolar lavage fluid which inclined toward respiratory system.
Hello,
Initially, SARS COV-2 virus when enters to the blood stream then it generally find the Angiotensin Converting Enzyme receptors (ACE-2) that are present upon the outer cell membrane. Virus spike protein gets attached to the ACE-2 receptor and then gets entered to the cell for its further replication process for the formation of its virions. Now, consequently it affects the another mechanism in the body which is regulated by ACE-2 receptor i.e. Renin angiotensin system that helps in the negative feed back inhibition to carry out homeostasis (to maintain blood pressure) in the body. As renin enzyme gets bind to the receptor and converts Angiotensinogen (inactivated protein form, zymogen form) to Angiotensin and then this protein makes a pressure to the arteriole cells to sustain the body blood pressure which has been fluctuated. But in the presence of bound virus, such system halts and fluctuates the homeostasis conditions.Therefore, it's more associated with the blood system as comparable to the respiratory tract. Here, one more thing is that to cause respiratory syndrome by affecting lungs, Virus needs to first infect blood cells and then the produced virions by such infection attached to the cilia of respiratory tract and blocks the oxygen/CO2 exchange mechanism due to the inflamation caused over there. So, we can analyse that it's an alternative approach of virus to infect the body for its own living.
Thanks a lot for the details and link@
Gaurav Sharma Muhammad Ghafoor Ali Ijaz Durrani
Emmanuel Ifeanyi Obeagu