Benzimidazoles, particularly those with a secondary amine group, can generate N-nitroso impurities, which maybe carcinogenic contaminants, under certain conditions; however, the synthesis of N-nitroso benzimidazoles is influenced by the molecular structure of the benzimidazole.

Yes, there is a chance for formations of N- Nitroso Impurities, as the Amine in Benzimidazole ring belongs to secondary amine group(N-H) which participates or takes part in nitrosation. (Nitrosation is a chemical reaction where NO group is attached to Molecule).

There were certain factors which influence the formation on N- Nitroso Impurities.