Endothelin-1 could be used for such induction, bcoz Endothelin-1 -induces constriction of arteries and veins

Thank you very much sir...

I really appreciate this advice as a big contribution  in my desired research

Dear Sir

Thank you very much for your Addition in knowledge list.

I really appreciate this advice as a significant contribution in my desired research

Thank you very very much.

Best regards

Md. Imtiazul Kabir ·

I'm not quite sure what you are looking for, but a well-established stroke model involves IV or IP injection of Rose Bengal (freshly prepared) followed by exposure of a selected portion of the brain surface to light (we use a fiber-optic light guide to put a small circle of light on the cerebral surface).  The light interacts with Rose Bengal and induces thromobosis of small vessels only in the illuminated volume, thereby producing a focal infarct.  I hope this helps.

I'm not sure what you are looking for, but one well-established model involves IV or IP injection of the dye Rose Bengal (freshly prepared, stock solutions go bad) followed by exposure of a selected portion of the brain to light (we use a fiberoptic light guide).  The light interacts with the Rose Bengal producing reactive oxygen species and other free radicals, thereby thrombosing small vessels only within the illuminated volume. This produces a nice focal infarct.

Nowadays endothelin-1 is the best option. Go ahead Dr. Kabir, cheers.

what will be cost of endothelin-1 what willbe dose and route of administration and mechanism of action please tell