In the acid condition, is thiol easily oxidized to disulfide or any others?
I prepared 2-propanol solution containing dodecanethiol for SAM. I checked the thiol group before and after addition of HCl by Raman, and after adding HCl the peak of thiol was disappeared. Do you have any suggestions on what had happened?
Thiols do not oxidize under acidic condition. They are very reactive under basic conditions (pH 8-9). I think the dissolved oxygen in the acid solution is to be blamed for the disappearance of -SH groups. You should de-gas your acid solution with argon or N2 gas, before using. I hope it will help...
Thiols do not oxidize under acidic condition. They are very reactive under basic conditions (pH 8-9). I think the dissolved oxygen in the acid solution is to be blamed for the disappearance of -SH groups. You should de-gas your acid solution with argon or N2 gas, before using. I hope it will help...
I would do, what dr Oommen suggested, if you want to get to know whether it is the oxidation or not, try to add small amount of Zn - you should see -SH group again. good luck.
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