What is the correct way to calculate confidence intervals of an AUC obtained by merging/pooling predictions from different test sets?

I have one question regarding the CIs of the AUROC calculated merging/pooling the predictions coming from different test sets. In one analysis, we use a sort of nested cross-validation approach,...

08 September 2018 4,141 0 View

Is there a general and model-independent way of calculating prediction intervals in machine learning for regression task?

01 February 2018 8,815 5 View

Post-pre change or post scores in predicting treatment response give different cross-validated r-squared. Which should I consider?

I have trained a machine learning model to predict the outcome of a therapy based on some pretreatment information. Outcome is based on a questionnaire that is administered both before (pre) the...

01 February 2018 9,334 3 View

In cross-validation, which is the AUC population parameter I really want to estimate?

01 February 2017 5,993 7 View

Which Bootstrap for Confidence Interval of AUC with Leave-Pair-Out-Cross-Validation?

I have to calculate the CI of the AUC (Roc) for a series of classifiers (e.g. Lasso, Random Forest, SVM) learned using the same test dataset, in order to identify the best model for this problem...

11 December 2016 258 4 View

Topic analysis with rarely occurring topic and small document corpora. Which technique should I use?

09 October 2016 1,912 3 View

Recursive feature selection with cross-validation in the caret package (R): how is the final "best" feature set selected?

08 September 2016 5,604 4 View

Power analysis in meta-regression?

04 May 2016 3,877 4 View

Does publication bias affect the meta-regression slope coefficient?

Hi everybody,differently than in meta-analyses, the effect of publication bias in meta-regression seems to me less severe for the slope coefficient, In my opinion, a bias in the slope coefficient...

04 May 2016 826 7 View

How is it correct to optimize a binary classifier output threshold with ROC and LPOCV?

Hello everyone and thank you in advance for you help! I'm building a screening tool with a machine learning algorithm. The model provides a probabilistic prediction (i.e. logistic regression,...

03 April 2016 4,379 7 View

How to compare two groups with only two measurements?

Hiiiii everyone! I have an enquiry on statistical analysis. I was looking for many forum and it's still cannot solve my problem. I want to compare means of two groups of data but only with two...

03 March 2021 8,796 3 View

Why does blocking with my immunogenic peptide cause nuclear fluorescence in ICC?

Hi all, I am validating a polyclonal antibody raised against human ANT4, through WB and ICC. In most of my controls, the antibody shows very little off-target binding, but when I pre-incubate the...

03 March 2021 5,999 3 View

Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence?

I am on the lookout for the Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence. Does anyone know where I can find it? Thank you in advance

03 March 2021 3,568 1 View

What kind of fluid could I use for a pitfall trap that also does not invalidate molecular testing?

Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...

03 March 2021 5,978 5 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Do we need to write protocol for a second study of a systematic review that has been registered and published?

I have conducted and published a systematic review and meta-analysis research with the topic related to public health and health pomotion (protocol was registed in PROSPERO). Now we want to...

03 March 2021 8,920 3 View

How to increase a model accuracy ?

dear community, my model is based feature extraction from non stationary signals using discrete Wavelet Transform and then using statistical features then machine learning classifiers in order to...

03 March 2021 6,994 5 View

Do I need to do linear regression before running mediation analysis using PROCESS MACRO by Hayes ?

I just wanted to check if I need to run a linear regression separately if I am using PROCESS MACRO to run mediation analysis. Thank you.

02 March 2021 4,359 3 View

Sample dilution for quantitative analysis using ELISA?

If the detection range is in ng/ml but the reference range is in ug/ml for a molecule or protein in serum or plasma .how to dilute and what is the initial volume to be taken for quantitative analysis

02 March 2021 7,670 3 View

Is There Any Feasible Method To Test Fluorescent Compounds Other Than Fluorescence Spectrometers ??

Is There Any Feasible Method To Test The Efficiency Of Fluorescent Compounds Other Than UV Spectrometers ? Suggestions Would Be Appreciated !

02 March 2021 5,785 3 View