REST2 stands for Replica Exchange with Solute Tempering and it is a sampling enhancement algorithm of molecular dynamics (MD) that uses fewer replicas but achieves higher sampling efficiency than standard temperature exchange algorithm. REST2 works by rescaling the force field parameters of the solute region according to a temperature parameter that varies across replicas. REST2 can be used for various applications such as conformation sampling, free energy calculation, and free energy landscape exploration.

To interpret your results, you may want to look at the average probabilities and the average number of exchanges of your replicas. The average probabilities indicate how often each replica visits each temperature level. Ideally, you want these probabilities to be uniform across replicas and levels, meaning that each replica has equal chance of visiting any temperature level. The average number of exchanges indicate how often each replica swaps its configuration with another replica. Ideally, you want these numbers to be high enough to ensure good mixing and ergodicity of the replicas.

Based on your results, it seems that your average probabilities are not very uniform, especially for replica 2 and 5 which have higher probabilities than the others. This may indicate that your temperature levels are not well distributed or that your simulation is not long enough to reach equilibrium. Your average number of exchanges are also not very high, ranging from 0.14 to 0.23 per cycle. This may indicate that your exchange acceptance rates are low or that your exchange frequency is too low.