Hi everyone, if I identify the amino acid sequences into epitope regions. what protocol, methodology or software can I use to propose a specific structure of antibody (Paratope)?
Hi, Alejandro.
If you have the sequence of amino-acid, you can put it in the next page and predict the possible structure of antibody that you are looking for.
https://swissmodel.expasy.org/
In addition, other methodologies are reported in the recent literature.
Article Antibody H3 Structure Prediction
Article RosettaAntibodyDesign (RAbD): A general framework for comput...
With kind regards,
Julián Sánchez.
Thank you so much, but it is not my question. How can propose the best hypothetical model of antibody to interact with the specific epitope?
Martin Heil this sound like an interesting question which you could help us.
For me, only will be necessary a specific amino acid chain of both (epitope and paratope) and after use a program (Swissmodel, which is free) for elucidating the relationship.
what is your opinion based on your experience dear Martin Heil ???
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