Insertion of beta amyloid as a TM dimer ?

26 September 2017 0 4K Report

Since Amyloid Precursor Protein (APP) cleavage leads to the production of the beta amyloid and the beta amyloid dimer is inserted as a TM dimer inside the membrane, I want to know if this insertion takes place before cleavage or after cleavage ? Also, what is the role of pore formation in this ?

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