Immune-mediated inflammatory diseases (IMIDs) are a heterogeneous group of diseases that have common pathogenic mechanisms. Among them, ailments such as colitis ulcerosa, Crohn's disease, celiac disease, collagenous colitis, rheumatoid arthritis, psoriatic arthritis, psoriasis, chronic urticaria, vitiligo or multiple sclerosis are mentioned. In the emergence of these diseases, the dysregulation of the host's immune response and chronic inflammation are involved.

Article Immune-mediated inflammatory diseases (IMIDs) and biologic t...

Article Immune-mediated inflammatory diseases: Progress in molecular...

It is also suggested that human microflora may play a role in the development of IMIDs.

https://www.frontiersin.org/articles/10.3389/fmicb.2016.01081/full#B12

I think inflammation is the core of medicine from minor injuries to the cancer

Pro-inflammatory effects can bei seen in contacts between particles and immune cells when orally or parenterally administered.

See english summary in

http://www.bmub.bund.de/fileadmin/Daten_BMU/Pools/Forschungsdatenbank/fkz_3711_62_205_partikel_innenraum_bf.pdf

and a case report from 1992: http://adc.bmj.com/content/archdischild/67/12/1475.full.pdf as well as http://www.who.int/medicines/publications/pharmacopoeia/2012-04-04TestsforParticulateContamination_QAS11-405_Final.pdf to understand the scope of the problem and how to address it.

Hi Dr Dennis,, many diseases are related to inflammation... Like

Infective disorder

Collagen vascular disease

Inflammatory bowel disease

Vasculitis

Etc.... Thanks

Persistent viruses such as cytomegalovirus (CMV) can be a source of inflammation. The pathogen burden (of which CMV is a key component) has also been linked to some inflammatory diseases. In my own research I have been looking for outbreaks of an unknown pathogen which appears to work via sub-acute immune manipulation. Have a look at the relevant sections at http://www.hcaf.biz/2010/Publications_Full.pdf