A vast number of very different drugs can cause musical hallucinations, such that these must be mediated by some quite general and non-specific mechanism.   Hence, I suspect there is no specific pharmodynamic mechanism for mania induction.

    Make a list of all the mania-inducing drugs, and I will wager they have no common pharmacological property.

I have seen it happen with quetiapine.

AMINE BENYAMINA, LUDOVIC SAMALIN. Atypical antipsychotic-induced mania/hypomania: a review of recent case reports and clinical studies. International Journal of Psychiatry in Clinical Practice, 2012; 16: 2–7.

Quetiapine Induced Hypomania: A Case Report and a Review of the Literature. Current Drug Safety, 2012, 7, 250-253

R. Bou Khalil, C. Baddoura

Hun Y. Millard, Barbara A. Wilson, MD and Douglas L. Noordsy.Low-Dose Quetiapine Induced or Worsened Mania in the Context of Possible Undertreatment. J Am Board Fam Med January-February 2015 28:154-158; doi:10.3122/jabfm.2015.01.140105

Quetiapine can also induce such states, it is true. The active metabolite of quetiapine, norquetiapine, is a very potent 5-HT1A partial agonist and a noradrenaline reuptake inhibitor, and this is apart from its 5-HT2C and alpha-2a antagonism.

I’ve seen switches with quetiapine, even at higher dosages, with aripiprazole 15 mg and with asenapine 20 mg. But never with risperidone (more than 0.5 mg/d obviously) or olanzapine.

My perspective is... Neither of the two SGAs would induce mania. Simply, neither if the twos would suffice to prevent at low doses and as monotherapy in some patients...

The most important reason is the leck of Impact of the drug. Olancapine for example is metabolized by Cytochrome 1A2, which itself can be induced by bencepyrene like grilled meat and especially smoke from cigarettes. Smoking patients often Need 40mg until they have a remarkeble drug Level in the blood (measured in the Steady state after 5 half-live periods of the drug - and olanzapine has a hals-live period of at least 36hours)

Risperidone is by 85% metabolized by Cyt 2d6, this System can be induced like other Systems too, but the most important reason is the genetic variaty. For example african People have probability of up to 25% beeing a rapid metabilizer and the western kaukasian race is nearby up to 2-5 percent. So you Need a drug Level as well. And when a drug Level is validated, high enough, you have to Question the Maniac Symptoms because all SGAs can induce impulsive Symptoms as a side effect...

When you have an Special case, you can send me the daily dose, the Symptoms and the measured drug Level in the Steady state and we can talk About.

Cheers,

CJ

Article Risperidone-induced mania: An emergent complication of treatment

Risperidone-induced mania: An emergent complication of treatment

Article Possible induction of mania and hypomania by olanzapine or r...

Article Risperidone-Induced Mania

Article Probable induction of mania by risperidone [2]

http://www.dusunenadamdergisi.org/ing/fArticledetails.aspx?MkID=1033 - Mania possibly induced by clozapine: a case report

https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1399-5618.2003.02258.x - Ziprasidone‐associated mania: a case series and review of the mechanism

https://link.springer.com/article/10.1007/s12325-008-0003-4 - Manic symptoms probably associated with short-term low-dose quetiapine use

https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/induction-of-manic-symptoms-by-novel-antipsychotics/D0D626566B118A596295A2D44C4EC20E - Induction of manic symptoms by novel antipsychotics

Article Olanzapine Induced Mania: A Case Report

Article Olanzapine-induced mania in bipolar disorders

http://ijps.tums.ac.ir/index.php/ijps/article/view/419 - Olanzapine-Induced Mania in Bipolar Spectrum Disorder:A Case Report

Article Olanzapine-Induced Mania in Bipolar Spectrum Disorder: A Case Report

Article Olanzapine-Induced Mania

https://www.jaacap.org/article/S0890-8567(09)60996-5/pdf - POSSIBLE ZIPRASIDONE-INDUCED MANIA

http://medind.nic.in/ibi/t10/i2/ibit10i2p112.pdf - Amisulpride induced mania

https://casereports.bmj.com/content/2012/bcr-2012-007388 - Repeated activation of mania by atypical antipsychotics in a patient

http://armaghanj.yums.ac.ir/article-1-735-en.pdf - Report of a Rare Case of Olanzapine and Risperidone Induced Hypomania