In the notch signaling pathway, what is Fringe activating?

19 February 2020 1 3K Report

Take a look at the notch signaling pathway in human from KEGG : https://www.genome.jp/kegg-bin/show_pathway?hsa04330

What is Fringe activating? It is not pointing to another gene or protein, it is pointing to an interaction. What does that mean?

Marco Fantuz

Fringe genes are glycosyltransferases which fucosylate the transmembrane receptor, modulating Notch signaling.

You might find more in this review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174579/

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