In Ionic Gelation Method Chitosan and TPP will be used to cross link and produce nanocapsules. Drug will be entrapped in the nanocapsules.
My question is whether only the drug will be present within the entrapment of Chitosan Nanocapsules or it will be entrapped with some Chitosan with in the entrapment?
Also let me know whether Poloxamer will help to reduce the aggregation of Nanocapsules in physiological fluids.
Hope my question is clear.
Thanks in advance
Hello RamKumar, In my opinion drug will be encapsulated in the core and with a coating of chitosan layer and Poloxamers or pluronics are used as surfactants in preparation of nanoparticles so it will definitely reduce the aggregation of nanocapsules in physiological fluids.
I think it depends on the type of the drug (physico-chemical characteristics) and on the method of preparation. Release profile and scanning electron microscopy will give evidence about drug location.
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