In my students and early physician days, between 1946-1960, also a few years after the WW II ended IE, acute or subacute, was often seen, mostly mitral. Almost an epidemic. It was a rough period of life during the war, so many of them had earlier badly or even untreatened angina and/or arthritic pains or swellings of their joints. The most often micro-organism seen was Staphylococcus. Since the time elapsed IE disappeared, so the last one I observed till my retiring (1990) was in 1974 or 1975, a typical case of aortic valve IE with fever, Osler nodes and subconjunctival microhaemorrhages, coming back from Germany. In spite of repeated sterile blood cultures he was successfully treatened with prolonged 50 million of Penicillin units- infusions daily till clinical cure. And after that, during next 15 yrs, and thousands of heart-patients, no more IE! Miraculous!
The infective endocarditis is characterized by vegetations which usually affect the left side of the heart in patients with underlying valvular lesions. Aortic regurgitation is more common in patients with infective endocarditis although both mitral and aortic valves are usually affected.
Aortic stenosis followed by mitral regurgitation. However, we observe sometimes in patients with chronic IE a combined aortic vitium (Stenosis & regurgitation)