Do G6PD deficiency harmfull for all cells? Why we only talk about rbc when it comes to G6PD deficiency?
Hi there,
NADPH is the molecule ensuring the reduction of oxidized glutathion into reduced glutathion. The latter is the main molecule of oxydative stress response. RBC are in charge to provide the NADPH necessary to oxydized glutathion reduction and G6PD is actually the only source of NADPH in RBC which makes the cell very dependent on the G6PD enzyme.
Hi there,
NADPH is the molecule ensuring the reduction of oxidized glutathion into reduced glutathion. The latter is the main molecule of oxydative stress response. RBC are in charge to provide the NADPH necessary to oxydized glutathion reduction and G6PD is actually the only source of NADPH in RBC which makes the cell very dependent on the G6PD enzyme.
They are less affected as they have a "mitochondrial source" of NADPH (from malic enzyme and isocitrate dehydrogenase activities) which RBC have not.
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