Is there any protocol available for in-vivo biocompatiblity testing of metallic implants inside C57bL/6 mice. The purpose of the studies is to evaluate cell response and histology. Articles are available for rats and rabbits but not for this mouse. For instance, in rats, people have implanted specimens into para-vertebral muscle and near the sciatic nerve. They have used 6 mm x 1.8 mm size specimens. What should be the size to do same in mentioned type of mouse. Guidance in this regard will be highly appreciated.