How much do neutrophils, microglia, and other immune cell activation and infiltration play a role after craniocerebral trauma?
Thanks for sharing my interest on this point, Tuo Li.
In 1980, I came upon a paper that said the autoimmune reactions met with ischemic brain trauma were far more intense than those seen in multiple sclerosis.
Another paper put down the autoimmune reactions provoked by Freund's adjuvant in EAE to be much weaker than those seen in MS.
Since then, I read countless papers dealing with mechanical brain trauma. Without spotting one that focused on its immune reactions.
Let alone one that compared them with those seen in other pathological conditions.
Sorry that I had first to correct a blunder in my comparison of the immune reactions of MS and EAE.
Indeed, more research should have been done on the different roles or functions of neutrophils, mast cells, monocytes, microglia, T cells, and B cells in the various forms of inflammatory reactions.
At least their role in removing debris and onko-osmotic balancing of intravascular and interstitial fluid.
All that seems to be known are the different timing of their appearance and persistence in acute and chronic tissue damages, varying with their degree.
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