If alpha-MSH agonists tan the skin, can alpha-MSH antagonist lighten it?

12 April 2018 1 10K Report

Also is it beneficial to propose a thesis and research this antagonist?

An already discovered antagonist is met- Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 and it has been proven to reduce alpha-MSH production.

John Heath

We use Nonapeptide-1 ( Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val ) and vectorised Oligopeptide-68 (MITF transcription factor modulator) in two of our commercial hyperpigmentation products, with great success.

see: https://www.peptidesciences.com/nonapeptide-1

Oligopeptide-68 is: Glycyl-L-arginylglycyl-L-alpha-aspartyl-L-tyrosyl-L-isoleucyl-L-tryptophyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-threonyl-L-glutamine

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