Thank u sir. I intend to do invitro studies

I'm not a clinician and cannot advice anything with treatment. But I study a major depressive disorder (MDD) susceptibility genes in genetic isolates where I found a high aggregation of the disease. In mapping genes of MDD in the isolates found reliable with other researchers findings and novel genomic regions with candidate genes...of my opinion, to have sucessful treatment with medications we should use these types of scientific findings and related pathways.

Hi Sarma

First of all, for doing a project you should have an insight of the research paradigm. The design and the discipline should be clearly defined. I am neither aware of your academic background nor your experience in this discipline. Well, doing a project is huge activity and need to emphasize pin pointedly the parameters you are planning. One aspect is working on the already existing therapeutic modalities or therapeutic agents in current use. If this is the case then other aspects are required to be considered. For example you could work on psychopharmacological responses, their interactions or mechanistic approaches. On the other hand, you could see the adverse effects or interactions in behavioral pattern and that comes in toxicology. But this all depends on the facilities available at your work place. Again, If you have clinical setup or otherwise an experimental model is more appropriate. I think, it is quite difficult to guide you without knowing your whereabouts, area of work, parameters accessible, instrumentation and facilities accessible.

this is for the presentation of thesis as partial fulfillment of my m.pharmacy. We do have a well equiped laboratory. Would like to study the effects of antidepressants on the body as in toxicology.

Well, What I get from your reply is that you are candidate for M.Phil in Pharmacy. Well there are many sub disciplines in Pharmacy, like pharmaceutics, pharmaceutical chemistry, pharmacology, pharmacognosy etc etc. However, I would stress on the area you are looking for., i.e. pharmacology (toxicology). You could choose any of the topics related to antidepressants. An example from my own students topics-- - Psychopharmacological assessment of -----(drug name)---- in experimental models of stress and anxiety. This could be accomplished by using many simple parameters like grasping strength test, exploratory behavior changes, rota-rod performance, learning and cognition behavior assessment, antinociception, water lick conflict for anxiety etc. However, it depends on the instrumentation and resources available at you work place. Other topics in the related disciplines with variable design and regimens could be used for your academic research. You could also use a comparison approach between two different drugs or the same drug with different regimens like acute and chronic. Hope this gives you insight to proceed with.

Regarding human facilities if available other clinical designs or data from specialized clinics could be assessed and presented. However, that depends on your access to such data or clinical records.

Thank you so much sir

U may contact Dr Ahsana Dar, HEJ Res. Instt., University of Karachi, Khi, Pakistan

If you are using clinical records, please make sure that you look into the ethical aspect of it. It will increase the chance of the research being published in a high impact factor peer reviewed scientific journal.