The toxicity of nanoparticles span over a large range from those which are relatively safe all the way to those which can potentially cause cancer. It is clear that the problem is tricky since it is a function of a number of variables including particle size and size distribution, agglomeration state, shape, crystal structure, chemical composition, surface area, surface chemistry, surface charge and porosity. In the middle of all this uncertainty, I would like an elaborate answer, advice, legislation, guide on who to safely deal with nanoparticles.