CMA technology, also known as molecular karyotype analysis technique (molecular karyotyping), is based on microarray genome copy number analysis technologies including comparative genomic hybridisation array (aCGH) technology and single nucleotide polymorphism microarray (SNP array) technology. CMA can detect unbalanced chromosome CNV at the whole genome level and can be used to identify chromosomal abnormalities, including those that are too small to detect by conventional karyotype analysis tiny chromosomal abnormalities.
Can you tell me what do you want to do with CMA?
Why not SNP array? SNP array not only be able to detect CNV, but also uniparental disomy(UPD) ,triploid, a certain level of chimeras.
I will start a facility of human molecular genetics in my university. I have worked in Berlin in 2008 on human molecular genetics. I used array CGH technology in the projects. So, I am more or less familiar with this technology. However, if I establish aCGH it would then turn into CMA as our knowledge accumulates. I need a sample project proposal to get funding prior to establishing a facility.
I strongly advise you to introduce the SNP-Array platform. It is more powerful than the aCGH and with better operation.I was responsible for the establishment of the CMA detection platform in our laboratory, and achieved great success. I choose Affymetrix Cyto HD arrays and Affymetrix Cyto750K arrays in our platform.
You can contact the local dealer, they will have a sample project you want. But you should carefully consider which platform to establish.
Sent you one of my published papers.Holp that will be helpful to you.
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