Dear Saadiya,
what drug are you working on? in fact, it is not easy to solubilize using DMSO. Maybe a slight warming and change in pH of the solution, without compromising the stability of your solution, can help. Add small amounts of the substance under constant stirring also facilitate
Acids go into base and bases go into acid. For a drug like prazosin, I have used a couple of drops of glacial acetic acid in a test tube, frapped on a vortex, then 25% of final volume with propylene glycol. If no crystals visible, then q.s. with water.
For injections, there chemicals to create suspensions of hard to dissolve drugs. Those won't work for in vitro work.
That is a terpene without an ionizable moiety. Should go into DMSO and I know others have done experiments with it. How did they dissolve it if not DMSO? It will take some kind of carrier like DMSO to hold it in solution.
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Pharmaceuticals
- Drugs