I prepared ternary amorphous solid dispersions using indomethacin and PVPVA using Poloxamer 407 as a dissolution enhancer however in my dissolution studies my physical mixture and my pure amorphous drug were lower than my pure drug however of course my solid dispersion formulations were than my pure drug as expected due to conversion to the amorphous form?
Hope you can help me
Hey Dean,
Can you provide some details on your dissolution studies and/or how you analyze your samples? Maybe this will give some clues.
Kind regards
Ann-Christin
How do you measure the concentration? HPLC?
Even though the amorphous drug recrystallizes, the solublity should normally not become lower than that of the crystalline drug. Otherwise maybe it crystallizes as an other polymorph.
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