I have a question with respect to Hydroxamic acid, In R-N(Acetyl)-OH , where R in alkyl chain, what is the pKa of hydroxyl group.

More Suvratha Krishnamurthy's questions See All

Do you need to normalise data before structured equation modelling?

I'm using covariance-based SEM software. Do I need to normalize the data before I run the SEM model? The SEM model is fine and the data is large (744). 1. Do I need to normalize the data before I...

15 April 2024 422 5 View

What should i do to make my sample soluble in HRMS compatible solvent (Acetonitrile, methanol or water)?

I want analyze my sample for HRMS, but my compound is not soluble in methanol, acetonitrile or water. what should i do to make my sample dissolve in any of the above mentioned solvent?

14 February 2024 6,945 1 View

How to increase the ebselen yield from the reaction?

I'm following the same procedure that is given in the research paper but I'm getting very low yield. Kindly suggest some ideas to increase my yield.

20 September 2023 2,293 1 View

Can I get the JCPDS File for K0.5Na0.5NbO3?

Have anyone worked on this material for Hydrogen generation or CO2 reduction?

12 June 2023 8,506 0 View

Information on TQM concepts in Equipment maintenance?

Research papers

27 February 2023 9,815 1 View

Can we use continuous demographic variables (age,income,work experiance) along with latent variables in SEM?

In structured equation modeling, we use latent variables.

04 January 2023 1,046 4 View

I am planning to do my PHD in marketing management.I'm interested in digital marketing.Can you pls suggest suitable topics?

I'm interested in digital marketing. Can you pls suggest suitable topics?

15 July 2021 3,240 17 View

Glucagon staining for human islets and iPSC derived islets?

Hello, I'm using a Rabbit Glucagon antibody from Abcam to stain human primary islets and iPSC derived islets for Glucagon along with other pancreatic cell markers such as PdX1 and C-peptide. The...

28 December 2020 1,560 0 View

How do I parametrize the EMSC model for ATR-FTIR spectra?

To be used for: Biological macromolecules in cells No. of spectra: 18 samples (Spectral range - 600 - 3600 cm-1) Looking for implementation in the 'UNSCRAMBLER' software. (looking for model...

10 May 2020 323 0 View

Creating cell profiler pipeline for cytoplasmic to nuclear translocation?

Hi everyone. I am newbie at cell profiler. I am trying to measure nuclear translocation of my protein of interest (in green channel) in cortical neurons. I also co-transfect these neurons with a...

25 June 2019 9,659 1 View

• What the possible Persistent Organic Pollutants and Heavy metals present in fluorspar, sediments, and water bodies around its mining area?

Approximate concentrations are require in compared with the WHO permissible limts

11 August 2024 2,723 1 View

Basis set and input instruction to calculate HOMO and LUMO using Orca for Imidazolium based organic salts?

Hey there, As a synthetic chemist delving into theoretical calculations for my imidazolium-based organic molecules, I would greatly appreciate any guidance on the appropriate input instructions...

09 August 2024 5,444 7 View

How to calculate CCS for Sodiated adduct ions and Multiply Charged Ions?

I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...

08 August 2024 8,329 0 View

Separation of organic acids-HPLC?

Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.

07 August 2024 8,782 3 View

The aqueous fraction of the hydroethanolic extract is showing the presence of palmitic acid. What is the mechanism responsible ?

Palmitic acid presence in aqueous fraction

05 August 2024 8,624 4 View

How to convert g/kg Humic acid dose to kg/ha?

I used humic acid at 0.044 g/kg soil in my pot experiment. But finally, I have to recommend kg/ha. Each pot's soil weight was 11 kg. What is the solution?

02 August 2024 7,186 6 View

Conjugation of PEG-Amine to an Amino Acid Using EDC?

I am attempting to conjugate PEG to an amino acid at the C-terminus, for the purposes of producing nanoparticles. I have been told that PEG modified with amine groups can be used for this purpose,...

31 July 2024 2,033 1 View

How to improve peaks separation in HPLC?

Hi everyone, I'd like to better separate two close peaks coming from a bioconversion sample, I'm currently using a C18 KromaPhase 4,6mm Ø.I. SCHARLAU, particle size (µm): 10, pore size (Å): 100,...

30 July 2024 435 3 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Culture fibroblasts with or without FGF2?

I'm new to primary human fibroblast culture and I'm studying aging using cells from old and young donors. Some research groups have used media supplemented with FGF2, so I cultured cells in the...

29 July 2024 3,030 2 View

Michael Rubin

These are very weak acids. pKa should be less than 18 in DMSO. I bet, it will be much easier to enolize your carbonyl functions if you employ strong bases.

pKa is is about 8 in water. HIs compounds will be hardly soluble in water, though.

Suvratha Krishnamurthy

Thank you everyone for your answers.