Most papers mention that the baseline shifts are due to technical issues related to the connection. Is there a way to correct these baseline fluctuations during analysis? I have been recording fiber photometry from rats and using pMAT from Tucker Davis technologies to analyze the data. I notice that in some animals, these baselines have shifted from zero, which, in turn, affects the average Z-score. Does anyone know how to normalize/correct these baseline fluctuations across animals?

I have provided an example trace of the average z-score PETH with a shifted baseline.