Hi,

I am planning to study cognitive impairment in PD. I will use rotenone as a neurotoxin and will infused it into substantia nigra and ventral tegmental area in SD rats, to induce PD and cognitive impairment. I choose ventral tegmental area because of its intensive projections to the cognitive domains such as prefrontal cortex, hippocampus, amygdala. I wonder that how reliable model is this? Do you have any suggestions or directions to study cognitive impairment in my rotenone-infused PD model?

Thank you.

Similar questions and discussions