We hypothesis that chronic biliary pancreatitis is associated with pancreatic cancer initiation. But we are stucked in setting up an animal model.
Bile infusion method can be used in acute pancreatitis model, but not chronic pancreatitis model.
Caerulein injection is for chronic pancreatitis, but not biliary pancreatitis.
We have tried duct obstruction method by ligation the common duct of bile and pancreas. Due to high the mortality of the animals, we had the experiment paused.
Dose anybody have any experience about that?
Thank you very much for your help. We appreciate any comments.
Dear Huiyi,
this is not easy. Your hypothesis is interesting. At least gall stones are associated with pancreatic cancer.
The only way to induce a type of biliary pancreatitis is with dibutyl chloride (DBTC) - see our inaugural paper that I could NOT attach (RG crashed on me):
Sparmann G, Merkord J, Jäschke A, Jonas L, Nizze H, Löhr M, Liebe S, Emmrich J (1997): Dibutyl dichloride-induced pancreatitis in rats - a model to study fibrosis in the pancreas. Gastroenterology 112: 1664-1672. [Editorial p. 1762]
Here, you create some inflammation/necrosis in the distal bile duct obstructing the papillary region. Write to me a message and I attach the pdf. Write to me anyway, please. With best wishes, Matthias
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