How to resolve the memory error "stack overflow" when use Autodock vina to choose flexible residues.?

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About exosome isolation?

Hi, All, I am relatively new for exosome isolation. I used an izon column 70nm to isolate exosomes from differentiated neural cells, but the concentrations were pretty low after NTA analysis (I...

01 July 2024 2,558 0 View

Questions on ISH (dat probe) on adult zebrafish brain (cryosection)?

I am working on using the dat probe (dopamine transporter), which has been successfully applied to the whole mount in situ hybridization in 5 dpf zebrafish; however, when I applied the same probe...

19 March 2024 9,806 1 View

Having both composite reliability and Cronbach's alpha above 0.6?

Composite reliability above 0.6, Cronbach's alpha above 0.6, and AVE above 0.5 are present simultaneously. Is this acceptable? Please share valid references to cite the same content." "Rho_c is...

06 March 2024 4,624 1 View

How to search key word "community" on Cochrane Library?

I'd like to search for some papers which is relevant to the elderly, and older adults in the community, but when I type the keyword "community", there is no result. This won't happen when...

05 March 2024 4,464 0 View

Should we prohibit the false statements from the papers published in academia journals?

Should we prohibit the false statements from the papers published in academia journals? The words that “Einstein's famous equation E=mc2” is a sentence directly copied from internet. It is a...

04 February 2024 5,499 15 View

Mitotracker live imaging?

We are trying to stain cholangiocytes with mitotracker green and perform confocal live imaging. However, once we added mitotracker, the entire monolayer of cells started to peal off from the...

27 January 2024 2,678 1 View

Zebrafish larvae (5 dpf) shrunk/smaller after adding NBT/BCIP?

I am currently working on whole-mount zebrafish in situ hybridization. The zebrafish larvae I am working on are 5 dpf. The protocol I am following is Bernard Thisse and Christine Thisse. The...

27 November 2023 8,510 0 View

LVTOT or LVHAR of doing macroscopic electrostatic potential in VASP ?

I know that lvhar includes the ionic potential and the Hartree potential, while lvtot is the total potential. I want to use the bulk plus band lineup method to calculate. In the bulk calculation,...

16 October 2023 9,884 0 View

What is the problem in current astronomical observation?

Light should be dispersion in the gravitational field: www.preprints.org/manuscript/202207.0145/v3 Therefore, to have a right measurement of the numbers and spectrogram of the celestial objects...

19 September 2023 266 3 View

How to calculate transition dipole moment of phonons?

Hi, Folks! I got some angle-dependent IR spectra of a crystal. I would like to make some DFT calculations to interpret these anistropic results. Accurate description of the direction of...

18 September 2023 5,540 2 View

How to analyze multiple phosphorilation sites?

Hello, I am currently analyzing some phosphoproteomics data, but I have peptides with multiple phosphorylation sites or phosphorylations together with carbamidomethylation or oxidation. How can I...

04 August 2024 8,432 3 View

Normality assumption for linear regression is The assumption of normality is whether for residual errors or predictor variavble?

When we conduct linear regression, there are several assumptions. The assumption of normality is whether the residual errors are normally distributed, not whether a predictor is normal?

31 July 2024 6,164 3 View

How to add Cr parameter in autodock?

When I run autogrid4 it says: autogrid4: ERROR: Unknown receptor type: "Cr" -- Add parameters for it to the parameter library first! Look forward to your reply.Thank you so much!

29 July 2024 488 0 View

AutoGrid and Autodock 4.2.6 window opens for 1 second then closes and there is no output files?

Good day, I am a student trying to work on Autodock for a project regarding Ligand-DNA interaction so i am quite new to molecular docking. i have followed tutorials and did all the steps...

28 July 2024 2,136 4 View

Is it possible to dock more than one drug in the same active site or pocket of a protein to study synergistic/antagonistic/additive properties?

I wanted to know whether we can observe the synergistic/antagonistic/additive properties of combinations or mixtures of compounds through docking analysis. But during docking preparation any...

28 July 2024 7,413 6 View

How apply Kao Residual Cointegration Test in eviews?

Kao's panel cointegration tests , is there anyone willing to explain me the eviews-9 output for the Kao's panel cointegration tests?

23 July 2024 5,051 4 View

When you express a protein, why do we express not only the domain we want, but also the protein around it?

I want to express STK4, and I've searched the paper for reference. When I check the protein kinase domain sequence for that kinase on Uniprot, it's 30-281, but the paper expresses the protein...

20 July 2024 4,951 1 View

Printing residues in an object in Pymol?

Hi! I am currently working on a protein where I have selected residues within 10A of its bound ligand in pymol. However, I can not find a way to print out what residues are contained in that group...

15 July 2024 1,727 1 View

Why Cl atom is not showing in docked comlex of molecule?

During the preparation of a ligand molecule in autodock or openbabel Cl atom is not showing in the .pdbqt file whereas it was present in the pdb and sdf file. Due to this Cl atom is not showing in...

13 July 2024 3,486 6 View

How do I identify And count the number of active sites of an adsorbent?

Jarosite is obtained from bioleaching residue and I want to determine if there are increased active sites biogenic jarosite compared to chemical synthetic jarosite.

10 July 2024 8,132 2 View