General Properties of molecules:
Molecular weight- 4000-6000 dalton.
pKa - Strongest acidic: -2.9
Strongeest Basic: -3.6
log P: -8
Polymorph - Amorphous in nature
Sterioisomer - Dextro
Want to prepare liposome for above mentioned properties of the molecule please suggest method & best suited lipids for manufacturing of liposomes.
Dear Avinash,
You can try methods described in the attached papers, including "Mozafari Method":
... 4.5. Encapsulation of therapeutics using Mozafari method:
... Encapsulation or entrapment of hydrophilic, hydrophobic or am-phiphilic compounds can be achieved by Mozafari method efficiently. This method has been employed for the encapsulation of poly- unsaturated fatty acids [117–119], the antimicrobial agent nisin [94,120], protease enzyme [121,122] and the anticancer drug 5- fluorouracil (5FU) [123,124]. Loading the hydrophobic molecules such as TQ to nanoliposomes using Mozafari method can be accomplished through the following three steps:
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