Previously I raised a question: why are you doing science. A lot of people responded and most of them say they love science. I have seen lot of researchers most of time they are sad, I observed most of them are quite frustrated; particularly students and researchers on ad hoc (project assistants, research associates, post doctoral researchers). My question is how to manage frustration in research it may be due to number of reasons (tension of grant, job security, unable to publish etc.), Please share your experience.