Hey all
I have synthesized BSA curcumin nanoparticle by the traditional method of desolvation. In this method curcumin (1mg/mL) was dissolved in ethanol and added dropwise at the rate of 1.5mL/min to the BSA solution in stirring condition. After synthesis the solution was washed thrice with MQ water and the amount of curcumin in supernatant estimated by UV spectroscopy at 425nm. 8% of glutaraldehyde (50uL) was used as a cross linker.
The encapsulation efficency obtained was only 12 %. Whereas literature reports more than 70%. (Article Curcumin-loaded bovine serum albumin (BSA) nanoparticles: ph...
How do I increase the encapsulation efficency?
To increase encapsulation efficiency of curcumin in BSA nanoparticles, optimize the drug-to-polymer ratio and modify the desolvation process by adding curcumin during synthesis. Additionally, consider adjusting stirring time, pH, and using different crosslinkers or stabilizers to enhance drug loading.
Thank you for your suggestion Abdelhak Maghchiche
Could you please suggest what would be the ideal drug to polymer ratio required in here?
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