Active ingredient of Berberis extract is Berberine which is know for Glucose Metabolism but absorption seems to be very poor. I searched some paper and found milk thistle when added with berberis, improves its absorption. Any help here will be highly appreciated, thank you in advance.
Rishi Modi
hi,
Nano-formulation such as nanoliposomes, nanomicelles, nanohydrogel, can improve solubility and stability of active compounds.
Thx Mokhtar for your answer, but I'm looking from the perspective of Bioavaibility.
Maybe the following papers will help you:
1. Lv X-Y, Li J, Zhang M, et al. Enhancement of Sodium Caprate on Intestine Absorption and Antidiabetic Action of Berberine. AAPS PharmSciTech. 2010;11(1):372-382. doi:10.1208/s12249-010-9386-z.
2. Rad SZK, Rameshrad M, Hosseinzadeh H. Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: a review. Iranian Journal of Basic Medical Sciences. 2017;20(5):516-529.
3. Godugu C, Patel AR, Doddapaneni R, Somagoni J, Singh M (2014) Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid. PLoS ONE 9(3): e89919.
4. Mohsen Imenshahidi and Hossein Hosseinzadeh. Berberis Vulgaris and Berberine: An Update Review. PHYTOTHERAPY RESEARCH Phytother. Res. 30: 1745–1764 (2016)
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