original sequence:

5'- ...CTCGGCATGAATCGC... -3'

3'- ...GAGCCGTACTTAGCG... -5'

.

Modification:

5'- ...CTC^GGCATGAA/TCGC... -3'. (where ^ denotes a single strand nick)

3'- ...GAG CCGTACTT /AGCG... -5'. (and / denotes double strand break)

.

Resulting DNA product (one has blunt end, another with sticky end):

5'- ...CTC -3'

3'- ...GAGCCGTACTT -5'

&

5'- TCGC... -3'

3'- AGCG... -5'

.

Aiming to result in blunt end and sticky end DNA species. May I know how can this be done preferably with CRISPR? Note that the distance between single and double strand break can varies as long as one DNA with blunt end and one DNA with sticky end. Hope the illustration is clear enough. Thank you.