Dear statisticans and HTA experts ,
I am newbie and working on my first model using a markov model with probabilities varying according to time in state. After synthesis clinical trials, unfortunately I have difficulties to derive transition probabilities from pooled HR. How to calculate shape and scale parameter of Weilbull distribution from this pooled HR?
I really appreciate your helps.
Kind regards
Cuc
Here is my R code that I used to obtain Weibull shape and scale parameters from my data. You just need to change the file labels to your own ones.
seeds
I hope that Andrew Paul McKenzie Pegman's answer works perfectly well for you.
In case it doesn't, please clarify some things:
- Probabilities varying with time in state and using Weibull distributions seems to say that you are not actually making a Markov model but that you are somehow including simulation of time to event with a Weibull distribution. Is that correct? Can you give some more detail on what you are doing?
- It seems impossible to me to estimate two Weibull parameters from one hazard ratio. However, since you have pooled data, why don't you use more information from the data than just the HRs?
- Since you say that you are a newbie: Do you have somebody mentoring or supervising your work?
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